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Tamixofen commonly known by its brand name Nolvadex is effective in treating metastic breast cancer not only in women but also in men. It is considered as an antagonist on the receptor of estrogen on the breast tissue. This is the commonly used therapy for early signs of breast-cancer. This is a substitute way to ovarian irradiation or oophorectomy (surgical removal of the ovaries). Patients who were proven to have tumors due to estrogen are most likely the one’s who can benefit from the Nolvadex treatment. This is also used in treating node-positive breast cancer on postmenopausal women following surgical treatments such as segmental mastectomy or total mastectomy. Estrogen is most commonly the cause of optimizing the effects of steroids. It can also help not only cancer patients but also those patients who are experiencing edema, gynecomastia (abnormal enlargement of the breasts of men) and female pattern fat distribution; all of this might happen if the estrogen levels are high. Furthermore, this can also be a sign that the Androgen level is low.
Nolvadex acts by competing with estrogen on the estrogen receptors of the target tissues and tumors. This in turn will decrease DNA synthesis on the target tissue and inhibiting the effects of estrogen as well. It is a nonsteroidal cause with effective antiestrogenic properties which contends with estrogen for binding sites. Side effects of this drug include:
- Nausea - Weight loss - Headache - Thinning of hair (since it’s a chemotherapeutic drug) - Vaginal dryness or pruritus - Edema on the hands and feet - Bone or joint pain - Depressed mood These are just some of the many effects of Nolvadex. Nonetheless, inform your physician prior to the possibility of experiencing these symptoms. Your physician will know what you need to do to prevent the occurrence of these side effects.